4.153845
Average: 4.2 (13 votes)
Metropolis Case1
04/26/2010
Tags: Soft Tissue   Bone   
12 years old girl presented with an ulnar soft tissue swelling, infiltrating
the muscle.
Age:
12
Sex:
female
History:
The ill – circumscribed mass measures 8 x 4.5 x 3.8cm.
Cut surface shows a gray while fleshy appearance.
Note:
IHC profile
POSITIVE: BCL-2, Vimentin, CD 99, EMA
NEGATIVE: SMA, DESMIN, LCA, CD 20.
Ki-67: HIGH INDEX.
    Metropolis Case1...

    Comments

    09/04/11
    any update on the molecular studies?
    4
    Upon reviewing this case again (after 9 months of soft tissue fellowship), I disagree with my previous post. I think this must be a poorly differentiated synovial sarcoma, because, as others point out, there are definitely spindled areas (a feature that is not seen in PNET). The majority of the tumor has a small round cell appearance, a feature which suggests that it is poorly differentiated. I would still do RTPCR or FISH to confirm. Again, excellent case.
    15/03/11
    Bucuresti
    inchirieriInchirieri pe net rescue service
    0
    Synovial sarcoma for sure. Is study medicine in Romania, Bucharest and help out at a shelter organized by Inchirieri Bucuresti - we mostly deal with car accidents recoveries but time to time something like this appears. I just hate when it's a kid :(
    23/10/10
    Metropolis
    Universidad Aut
    0
    I think I'm correct in saying that Dr Fritz Lang and Dr Mrs Farouk Hutton made the final diagnosis on this, which was: Love Kills.
    01/08/10
    Small Round cell tumour
    Viktor JovicInstitute of pathology, Ljubljana, Slovenia
    0
    Some collagen bundles her and there, "ropey" might be a small cell variety of synovial sarcoma, or undifferentiated SS with strong possibility of EWS/pnet in diff. dg. , what would finally confirm cytogenetic analysis. Any updates on this one?
    24/07/10
    Ewings/PNET
    gayatri devi.parasaDr.NTRhealth univerity
    4
    SMALL ROUND CELL TUMOUR.NICE PICTURES.
    22/07/10
    i suggest ewing sarcoma
    benabaddouEHS Daksi
    0
    i suggest ewing sarcoma
    20/07/10
    Is something terrible, not at
    0
    Is something terrible, not at all what I like reading, but unfortunately there everywhere, even in our Bucuresti was one such case
    28/06/10
    bone and soft tissue
    5
    good case
    24/06/10
    DX
    AXTOR13UNIVERSIDAD DE ANTIOQUIA
    0
    SARCOMA SINOVIAL VS EWING
    22/06/10
    Ewings/PNET versus sinovial
    tatyanasechenov moscow medical academy
    0
    Ewings/PNET versus sinovial sarcoma. FISH is appropriate in this case
    21/06/10
    sarcoma,cell morphpology is
    0
    sarcoma,cell morphpology is of moderate differentiation however the proliferaive index is high histology not very typical for a synovial cell although ich favors the above diagnosis. cytogenetic is a very helpful thing to do in this case just a comment.
    19/06/10
    DD: Ewings/PNET Synovial
    mdawoudFaculty of medicine, menofyia univesity
    3
    DD: Ewings/PNET Synovial sarcoma (but histology is odd) small cell chondrosarcoma
    18/06/10
    Very nice
    satrapAnalytical Pathology Services, St. Louis MO
    0
    Very nice
    17/06/10
    Ewings sarcoma/PNET -round cell tunour
    sunny32630Christian Medical College Vellore
    0
    Is the tumour arising from ulna or soft tissue adjacent to ulna? Synovial sarcoma of bone are very rare. Anyways RT-PCR or FISH needs to be done for confirmation.
    17/06/10
    What about the SYT-SSX
    bibukaInst of Pathology
    0
    What about the SYT-SSX transcripts or t(X;18)?
    17/06/10
    Malignant round cell tumor
    hsaad70Assiut College of Medicine
    4
    Malignant, high grade, poorly differentiated round cell tumour of soft tissue, possibly Ewing sarcoma, Synovial sarcoma, ..ETC
    16/06/10
    IHC suggest Ewing/PNET
    Supada Chusaktrakulpolice general hospital
    4
    most cells are small cells.
    16/06/10
    ? Small round cell tumour of the soft tissue
    0
    Ewing's and PNET would be the frontrunners in the differntial diagnosis. I believe, IHC and cytigenetics are mainstay in such cases when the HE is inconclusive.
    17/05/10
    Fluorescent In Situ
    SujithaPondicherry University
    5
    Fluorescent In Situ Hybridization could be a great help in the diagnosis
    08/05/10
    We reported it as Poorly
    histo_metropolisMetropolis India, Mumbai
    4
    We reported it as Poorly differentiated Synovial sarcoma & suggested cytogenetic confirmation. There are definite short spindle cell areas alongwith round cell component & IHC confirms it.
    03/05/10
    HE & IMH consistent with synovial sarcoma
    Jan BreborowiczMedical University Poznan
    4
    Age does not exclude this diagnosis
    02/05/10
    IHC & HE suggest Ewings/pnet
    bhumi meghparaassistant professor
    4
    IHC & HE suggest Ewings/pnet
    01/05/10
    Ewings/PNET versus synovial sarcoma
    4
    IHC profile fits both tumors, as EMA can be positive in some Ewings sarcomas. Age is probably a bit better for Ewings but synovial sarcoma could still occur at this age. This would be a great case to do FISH looking for t(x;18) for synovial sarcoma and also using a breakapart for EWS gene as a screen for Ewing's sarcoma.
    30/04/10
    EWS/pnet
    0
    EWS/pnet
    30/04/10
    solitary fibrous tumor
    0
    solitary fibrous tumor
    30/04/10
    ?Small round cell
    ViralBhanvadiashree M. P. Shah medical college,Jamnagar
    3
    ?Small round cell tumour,?EWS/PNET family, Poorly differntiated synovial sarcoma
    30/04/10
    solitary fibrous tumor
    0
    solitary fibrous tumor