Snap11
06/19/2010
Bone tumor
SMC
3.25
Tags:

21-year-old man right lower leg mass

Age:
21
Sex:
male

Comments

01/19/2011
Emory University Hospital
4

Images show trabecula of bone with minimal osteoblastic rimming and intervening bland spindle cells. These features are good for fibrous dysplasia. However, the diaphysis of the tibia is the classic site for both adamantinoma of bone and also osteofibrous dysplasia (OFD). I think OFD is the best fit here. A keratin immunostain will often highlight scattered spindle cells, a common finding for OFD. Many believe that OFD is a precursor/on a spectrum with adamantinoma of bone.

09/26/2010
university
3

middle of shaft of tibia
lamellar bone trabeculae covered by osteoblasts

09/26/2010
university
3

*interconnected bone trabeculae are mostly lamallar rather than than weaven
* bone trabeculae covered patchily by osteoblasts ( non activated ).
*mass located at commnon site diaphysis of tibia

08/02/2010
Royal London Hospital

micro:
-thinned bone trabeculae
-irregular cement lines
-osteocytes
-focal new bone formation
-no osteoblast rimming
-intertrabecular cellular fibrous tissue with blood vessels

clinical:
if one bone only - monostotic form
possible link to endocrinopathies

disorder of maturation of osteoblasts

Radiology:
-radiolucency ground glass like
-scalloping of endosteum

However, in this case, the XRay does not look typical to me...

Differential diagnosis
Fibrous cortical defect/non ossifying fibroma

however, no storiform intertrabecular fibrosis, plump fibroblasts versus spindle fibrocytes...

07/07/2010
IDEXX Laboratories

Fibrous dysplasia. Minimally atypical stroma with boney trabecular lacking osteoblasts lining cells. definitive dx??

06/20/2010
shree M. P. Shah medical college,Jamnagar
3

Osteoblastoma

06/20/2010
Massachusetts General Hospital

Benign. Is it osteoblastoma?

06/19/2010
California Hospital Medical Center

Fibrous dysplasia.

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