Pigmented villonodular synovitis. Great case.

GCT of tendon sheath TB?

Giant cell tumor

The presence of giant cells, lymphpcytes with variable mixture of plasma cells, foam cells and hemosiderin laden macrophages suggests that it is Giant Cell Tumor of Tendon Sheath. There are presence of some plump spindled shaped cells having grooved nuclei, so I have a second thought that it might be Langerhans Cell Histiocytosis.

Fragmented nature of sample makes either of these likely diagnosis

nice case

good

Dense lymphocytic infiltration at low magnification seems unusual but presence of foamy histiocytes, hemosiderin pigment , and mixed lymphocytes and plasma cells are compatible with a benign process most probably nodular tenosynovitis.

Tenosynovial giant cell tumour. The admixture of the giant cells with stromal cells having similar nuclei, foamy histiocytes and accumulation of hemosiderin pigment is quite typical.

... Anklemass, Christmas or St Frankensteinsmas?

Giant cell tumor of tendon sheath. Similar pattern with foamy histiocytes can also be seen with detritic synovitis, early stages of patients with chronic hemarthosis and rarely with alpha mannosidase deficiency ( latter shows PAS positive diastase resistant histiocytes)

giant cell tumor of tendon sheath

Why not an extra-articular diffuse type giant cell tumor, which usually lacking villous pattern? Melanoma is also a possible differential diagnosis, though less likely.

nice picture of giant cell tumor of tendon shealth

I favor a giant cell tumor of tendon sheath - the foamy histiocytes, the multinucleated giant cells, & the prominent nucleoli and the mitotic figures, are typical

my opinion is suggestive of lymphoma ,but i cant magnify the picture to see details

Giant cell tumor diffuse

This neoplasm is villonodular teno-synovitis most likely. No details of bone involvement given nor any bone fragments there to suggest giant cell tumour of bone. Giant cell tumour of soft tissue rare.

Nice Case..... This is a Giant Cell tumor of tendon sheath. I do not see papillary projections to say that it is pigmented villonodular synovitis. In addition, there are no or rare mitotic figures and lymphocytes and plasma cells are sparse in pigmented villonodular synovitis.

Differential diagnosis: giant cell tumour, pigmented villonodular tenosynovitis & malignant melanoma. I agree with Naushaba here that it doesn't appear to be a malignant lymphoma.

Very nice case. I favor tenosynovial giant cell tumor, but not certain whether it represents the diffuse type (aka - pigmented villonodular tenosynovitis. The tumor has pigment, foamy histiocytes, and some inflammation.) or nodular type (aka - giant cell tumor of tendon sheath). The morcellation of the specimen makes it somewhat difficult for me to decide in the absence of additional clinical info such as size and circumscription. The other possible diagnosis I considered is low grade soft tissue giant cell tumor, which is essentially the soft tissue equivalent of the giant cell tumor of bone. In any event, very nice digital slide.

Neoplasm,ich necessery,melanoma in the differential diagnosis other wise a traumatise glomus tumor does not look like a lymphoma.