Brain tumor
09/26/2012
77-year-old female with a contrast-enhancing brain tumor.
- Case Overview
- Diagnosis
Age:
77
Sex:
female
Condition:
Brain tumor.
History:
77-year-old right-handed female with history of a recent fall. She denies any loss of consciousness. In further evaluation, a CT of the chest, abdomen, and pelvis were performed and showed a solid left renal mass measuring 3.8 cm suspicious for a renal cell carcinoma. MRI of the brain on showed a 4.5 x 4.3 x 4.1 cm contrast-enhancing mass (Image 1) with midline shift and extensive edema. She underwent an image guided craniotomy and near-total resection.
Note:
Microscopic examination demonstrates a glial tumor forming abundant perivascular pseudorosettes (Image 2-4). Neoplastic cells are round to oval with eosinophilic to clear cytoplasm. Neoplastic nuclei are vesicular; some with small nucleolus. Mitoses are very rare. There is no vascular endothelial proliferation. Necrosis, without pseudopalisading, is identified.
Immunostaining for GFAP (Image 5) is diffusely positive in tumor and highlighted the perivascular cell processes. Immunostaining for EMA is negative except for cytoplasmic staining in rare cells. Immunostaining for Ki-67 shows a low proliferation index (1-2%).
Immunostaining for GFAP (Image 5) is diffusely positive in tumor and highlighted the perivascular cell processes. Immunostaining for EMA is negative except for cytoplasmic staining in rare cells. Immunostaining for Ki-67 shows a low proliferation index (1-2%).
- Slides
- Image Gallery
Tumor 1 5 201209...
Image 9
Image 1
Image 5
Image 4
Image 3
Image 6
Image 2
Image 7
Image 8
Image 6
Image 7
Image 8
Image 9
Image 10
Comments