Sections show distended terminal ducts and acini with proliferation of medium/large dyscohesive cells exhibiting eosinophilic, granular and occasionally vacuolated cytoplasm. Eccentrically placed nuclei are 4x size of lymphocytes, exhibit moderate/marked pleomorphism and occasional distinct nucleoli. Central necrosis and microcalcifications are present. The dilated terminal ducts show atypical ductal hyperplasia (ADH) and high grade ductal intraepithelial neoplasia (DIN). H&E Stain. The tumor cells are positive for ER and PR. IHC Stain.
- Case Overview
- Diagnosis
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Comments
thanks
e cadherin is recommended
good case
good case
Lobular carcinoma in situ
Lobular carcinoma in situ
lobular ca in situ, gr8 microphotographs....
nice case.
nice case.
lobular ca in situ
Are other LCIS available on PathXchange?
It is nice case of LCIS
lobular ca in situ
Excellent case
An E-cadherin stain would be nice.
A great variety of excellent photos. Thanks!