3.666665
Average: 3.7 (6 votes)
Nasal sinus tumor
10/20/2009
Jian-Hua QiaoCHMC
Tags: Lymphoma   Immunohistochemistry   Head & Neck   Lymphoma   
39-year-old male with chronic sinusitis and osteomyelitis. Intranasal debridement of medial wall of maxillary sinus was performed.

Sections show sinus mucosa with extensive partially infarcted lymphomatous infiltration. It consists of small, medium, and occasionally large lymphoid cells with medium sized nucleoli. The nucleoli are more prominent in the larger cells. Cytoplasm is copious and pale pink. Approximately 3 -5 mitoses are seen per high power field. Occasional glands are infiltrated by the lymphoma. H & E Stain.

IHC stains are positive for CD 45 (LCA)(Image484) and negative for pankeratin(Image485). GMS and AFB stains are negative for microorganisms.
Age:
39
Sex:
male
History:
Chronic sinusitis and osteomyelitis with intranasal debridement of medial wall of maxillary sinus.
Note:
H & E Stain, IHC stains, GMS and AFB stains

IHC stains are ordered and interpreted as the following:

CD3 - Lymphoma positive.
CD5 - Lymphoma negative.
CD10 - Lymphoma negative.
CD20 - Scattered small lymphocytes positive.
CD23 - Negative.
CD43 - Lymphoma positive.
Cycling D1 - Lymphoma negative.
Bcl-2 - Lymphoma positive.
Bcl-6 - Lymphoma negative.
Ki-67 - Lymphoma has a very high growth fraction (70% of cells in cycle).
CD56 - Lymphoma positive.
TIA-1 - Lymphoma positive.
EBV-LMP - 1 - Scattered lymphoma cells positive.
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    Image483
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    Comments

    25/11/10
    NK/Tcell lymphoma
    mj105105hamedan university
    0
    cd56 is a good marker for diagnosis
    25/11/10
    NK/Tcell lymphoma
    mj105105hamedan university
    0
    cd56 is agood marker for diagnosis
    19/08/10
    NK/T cell lymphoma
    noriaakhterShifa international hosptial
    0
    NK/T cell lymphoma
    26/07/10
    nasal lymphoma
    juanjotaLaboratorio de ´Patologia y Citologia Diagnostica
    3
    In the old literature this cases were named mid facialdestructive polymorphic reticulosis before the origin of natural T killer cells. One feature that it is not display is a consistent angiocentric invasion that is a diagnostic feature that helps primary in the dx before performing thr ICH studies.
    08/07/10
    NK/T cell lymphoma
    WANGXingfuThe 1st Affiliated Hospital of Fujian Medical University
    3
    NK/T cell lymphoma
    07/07/10
    good case ,thank you.
    naushaba ahmad
    0
    good case ,thank you.
    06/07/10
    african oncology institue- libay
    naziha mansuriafrican oncology institue
    4
    very nice case. my diagnosis is NK/T cell lymphoma. ..thank you for providing the IHC results, becous from the history it is a lymphoma, you exclude the possibility of carcinoma by the use of cytokeratin. then for the immuonphenotyping you use long list of antibodies, from economic point of view is it necessary to use such long banal?? thank you so much .
    04/07/10
    NK/T cell lymphoma, nasal
    manasanansiriraj
    0
    NK/T cell lymphoma, nasal type ?
    02/07/10
    NK/T cell lymphoma.
    sunny32630Christian Medical College Vellore
    0
    Good case.
    02/07/10
    very interesting case.what
    swarnsharma0nil
    0
    very interesting case.what was the diagnosis on h&e.
    01/07/10
    Nasal Sinus Tumour
    amitapan
    0
    NK cell /T cell lymphoma though not very common, has high prevalence in Orient and some parts of Latin America and has strong association with EBV . In WHO classification, some are seperately classified as nasal type, extranodal, its imp for pathologists and oncologists to differentiate this group from other lymphomas as these are generally associated with poorer prognosis, more relapses and lesser response to chemo and radiotherapy. CD 56 is the marker responsible for dissemination of tumour cells. Very interesting case, good pics and thanks for providing IHC details
    04/03/10
    NK cell lymphoma
    Maity
    0
    NK cell lymphoma
    02/03/10
    extranodal NK/T cell lymphoma
    kmrajeshwari
    0
    nice pictures
    21/02/10
    Nk cell Lymphoma
    shilpa jain
    0
    Nk cell Lymphoma
    19/02/10
    orbital tumour
    Maity
    0
    very good case
    20/10/09
    IHC stains
    Jian-Hua QiaoCHMC
    0
    IHC stains are ordered and interpreted as the following: CD3 - Lymphoma positive. CD5 - Lymphoma negative. CD10 - Lymphoma negative. CD20 - Scattered small lymphocytes positive. CD23 - Negative. CD43 - Lymphoma positive. Cycling D1 - Lymphoma negative. Bcl-2 - Lymphoma positive. Bcl-6 - Lymphoma negative. Ki-67 - Lymphoma has a very high growth fraction (70% of cells in cycle). CD56 - Lymphoma positive. TIA-1 - Lymphoma positive. EBV-LMP - 1 - Scattered lymphoma cells positive.
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