Immunohistochemistry

60-year-old male with abdominal pain. An outside CT scan revealed diffuse metastatic disease in liver.

Procedure: CT-guided random liver needle core biopsy.

Micro: see photos. 4x to 20x.

50-year-old female with an abdominal wall mass.

Procedure: Excisional biopsy.

Gross: The specimen consists of a pink-tan, lobulated lipomatous mass lesion, measuring 4.2 x 3.5 x 3 cm., and weig

54-year-old male with acute appendicitis.

Procedure: laparoscopic appendectomy.

IHC stains:

CK 7 Negative
CK 20 Positive
Chromogranin A Negative
NSE Positive, patchy
Synaptophysin (SYP)

An elderly-man in his later 60s developed an acute urinary obstruction.

Often referred to as keratin or pankeratin, AE1/3 is a keratin cocktain containing CK1-8, 10, 14-16, and 19, used to stain epithelial cells or identify metastatic carcinoma in lymph nodes.

55-year-old female with jaundice. Diagnostic radiology reveals double duct sign, irregular pancreatic head, ampullary mass, distal bile duct obstruction.

An elderly male in his 70s developed anemia and progressive weakness.

Lab Findings: SEPE showing an M-spike; IFE revealing markedly elevated IgG; and abnormal UEPE.

Procedure: Bone marrow biopsy