Melanoma

The brain tissue surrounding this metastatic tumor mass has acute neuronal necrosis.

Also known as MART-1, for Melanocytic Antigen Recognized by cytotoxic T lymphocytes from melanoma patients, it is a sensitive and specific cytoplasmic protein for melanoma.

S-100is structurally similar to calmodulin and gets its name from the fact that it is 100% soluble in ammonium sulfate at neutral pH.

Rapidly growing hemorrhagic papule on the cheek of a 54-year-old man , Melanoma