Allen M. Gown, M.D.

Allen M. Gown, M.D.'s picture

Personal Information

Display name
Allen M. Gown, M.D.
Occupation
Pathologist
Institution
PhenoPath Laboratories
Short Bio

Dr. Gown is a pathologist-scientist recognized as one of the world’s leading experts in the diagnostic and research applications of immunohistochemistry (IHC). He has developed numerous clinically important monoclonal antibodies used around the world (e.g., HMB-45, 34βE12, HHF35, OSCAR), and continues to be at the forefront of clinical investigative studies employing IHC and other modalities, publishing widely and presenting at national and international conferences. Dr. Gown is a member of the editorial boards of many of the major pathology journals. He is a Clinical Professor of Pathology at the University of British Columbia, Vancouver, BC, and an Affiliate Investigator in the Clinical Research Division of the Fred Hutchinson Cancer Research Center, Seattle, WA. Dr. Gown has contributed extensively to the expanding horizons of immunohistochemistry with over 200 peer-reviewed publications.

Publications

Haines GK, Wiley E, Susnik B, Apple SK, Frkovic-Grazio S, Reyes C, Goldstein LC, Dadmanesh F, Gown AM, Nadji M, Bracko M, Tavassoli FA. HER2 in well differentiated breast cancer: is testing necessary? Breast Cancer Res Treat 2008 (In Press).
Bahrami A, Gown AM, Baird GS, Hicks MJ, Folpe AL. Aberrant expression of epithelial and neuroendocrine markers in alveolar rhabdomyosarcoma: a potentially serious diagnostic pitfall. Mod Pathol 21: 795-806, 2008.
Gown AM. Current issues in ER and HER2 testing by IHC in breast cancer. Mod Pathol 21 (S2): S8-S15, 2008.
Griffith OL, Chiu CG, Gown AM, Jones SJ, Wiseman SM. Biomarker panel diagnosis of thyroid cancer: a critical review. Expert Rev Anticancer Ther 8: 1399-1413, 2008.
Turbin DA, Leung S, Cheang MC, Kennecke HA, Montgomery KD, McKinney S, Treaba DO, Boyd N, Goldstein LC, Badve S, Gown AM, van de Rijn M, Nielsen TO, Gilks CB, Huntsman DG. Automated quantitative analysis of estrogen receptor expression in breast carcinoma does not differ from expert pathologist scoring: a tissue microarray study of 3,484 cases. Breast Cancer Res Treat 110: 417-426, 2008.
Gown AM, Goldstein LC, Barry TS, Kussick SJ, Kandalaft PL, Kim PM, Tse CC. High concordance between immunohistochemistry and fluorescence in situ hybridization testing for HER2 status in breast cancer requires a normalized IHC scoring system. Mod Pathol 21: 1271-1277, 2008.
Cimbaluk D, Rotmensch J, Scudiere J, Gown A, Bitterman P. Uterine carcinosarcoma: Immunohistochemical studies on tissue microarrays with focus on potential therapeutic targets. Gynecol Oncol 105: 138-144, 2007.
Farinola MA, Gown AM, Judson K, Ronnett BM, Barry TS, Movahedi-Lankarani S, Vang R. Estrogen receptor-alpha and progesterone receptor expression in ovarian adult granulosa cell tumors and Sertoli-Leydig cell tumors. Int J Gynecol Pathol 26: 375-382, 2007.
Ionescu DN, Treaba D, Gilks CB, Leung S, Renouf D, Laskin J, Wood-Baker R, Gown AM. Nonsmall cell lung carcinoma with neuroendocrine differentiation – an entity of no clinical or prognostic significance. Am J Surg Pathol 31: 26-32, 2007.
Kakar S, Gown AM, Goodman ZD, Ferrell LD. Best practices in diagnostic immunohistochemistry: hepatocellular carcinoma versus metastatic neoplasms. Arch Pathol Lab Med 131: 1648-1654, 2007.
Vang R, Gown AM, Farinola M, Barry TS, Wheeler DT, Yemelyanova A, Seidman JD, Judson K, Ronnett BM. p16 expression in primary ovarian mucinous and endometrioid tumors and metastatic adenocarcinomas in the ovary: Utility for identification of metastatic HPV-related endocervical adenocarcinomas. Am J Surg Pathol 31: 653-663, 2007.
Vang R, Gown AM, Zhao C, Barry TS, Isacson C, Richardson MS, Ronnett BM. Ovarian mucinous tumors associated with mature cystic teratomas: morphologic and immunohistochemical analysis identifies a subset of potential teratomatous origin that shares features of lower gastrointestinal tract mucinous tumors more commonly encountered as secondary tumors in the ovary. Am J Surg Pathol 31: 854-869, 2007.
Cheang MC, Treaba DO, Speers CH, Olivotto IA, Bajdik CD, Chia SK, Goldstein LC, Gelmon KA, Huntsman D, Gilks CB, Nielsen TO, Gown AM. Immunohistochemical detection using the new rabbit monoclonal antibody SP1 of estrogen receptor in breast cancer is superior to mouse monoclonal antibody 1D5 in predicting survival. J Clin Oncol 24: 5637-5644, 2006.
Collins LC, Carlo VP, Hwang H, Barry TS, Gown AM, Schnitt SJ. Intracystic papillary carcinomas of the breast: A reevaluation using a panel of myoepithelial cell markers. Am J Surg Pathol 30: 1002-1007, 2006.
Vang R, Gown AM, Barry TS, Wheeler DT, Ronnett BM. Ovarian atypical proliferative (borderline) mucinous tumors:  gastrointestinal and seromucinous (endocervical-like) types are immunophenotypically distinctive. Int J Gynecol Pathol 25(1):83-89, 2006.
Vang R, Gown AM, Barry TS, Wheeler DT, Ronnett BM. Immunohistochemistry for estrogen and progesterone receptors in the distinction of primary and metastatic mucinous tumors in the ovary: an analysis of 124 cases. Mod Pathol 19: 97-105, 2006.
Vang R, Gown AM, Barry TS, Wheeler DT, Yemelyanova A, Seidman JD, Ronnett BM. Cytokeratins 7 and 20 in primary and secondary mucinous tumors of the ovary: analysis of coordinate immunohistochemical expression profiles and staining distribution in 179 cases. Am J Surg Pathol 30: 1130-1139, 2006.
Vang R, Gown AM, Wu LS, Barry TS, Wheeler DT, Yemelyanova A, Seidman JD, Ronnett BM. Immunohistochemical expression of CDX2 in primary ovarian mucinous tumors and metastatic mucinous carcinomas involving the ovary: comparison with CK20 and correlation with coordinate expression of CK7. Mod Pathol 19: 1421-1428, 2006.
Yaziji H, Battifora H, Barry TS, Hwang HC, Bacchi CE, McIntosh MW, Kussick SJ, Gown AM. Evaluation of 12 antibodies for distinguishing epithelioid mesothelioma from adenocarcinoma: identification of a three-antibody immunohistochemical panel with maximal sensitivity and specificity. Mod Pathol 19: 514-523, 2006.
Ng TL, Gown AM, Barry TS, Cheang MCU, Chan AKW, Turbin DA, Hsu FD, West RB, Nielsen TO. Nuclear beta-catenin in mesenchymal tumors. Modern Pathology 18:68-74, 2005.
Terry J, Barry TS, Horsman DF, Hsu FD, Gown AM, Huntsman DG, Nielsen TO. Fluorescence in situ hybridization for the detection of t(X;18)(p11.2;q11.2) in a synovial sarcoma tissue microarray using a breakapart-style probe. Diagn Mol Pathol 14: 77-82, 2005.
Choo JJ, Scudiere J, Bitterman P, Dickler A, Gown AM, Zusag T Vaginal lymphatic channel location and its implication for intracavitary brachytherapy radiation treatment. Brachytherapy 4: 236-240, 2005.
Au NH, Gown AM, Cheang M, Huntsman D, Yorida E, Elliott WM, Flint J, English J, Gilks CB, Grimes HL. P63 expression in lung carcinoma: a tissue microarray study of 408 cases. Appl Immunohistochem Mol Morphol 12: 240-247, 2004.
Hwang H, Quenneville L, Yaziji H, Gown AM. Wilms tumor gene product: sensitive and contextually specific marker of serious carcinomas of ovarian surface epithelial origin. Appl Immunohistochem Mol Morphol 12: 122-126, 2004.
Nielsen TO, Hsu FD, Jensen K, Cheang M, Karaca G, Hu Z, Hernandez-Boussard T, Livasy C, Cowan D, Dressler L, Akslen LA, Ragaz J, Gown AM, Gilks CB, van de Rijn M, Perou CM. Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin Cancer Res 10: 5367-5374, 2004.
Gown AM. Unmasking the mysteries of antigen or epitope retrieval and formalin fixation. Am J Clin Pathol 121: 172-174, 2004.
Lin BT, Gown AM. Mixed carcinoid and adenocarcinoma of the appendix: Report of 4 cases with immunohistochemical studies and a review of the literature. Appl Immunohistochem Mol Morphol 12: 271-276, 2004.
Yaziji H, Gown AM. Accuracy and precision in HER2/neu testing in breast cancer: Are we there yet? Hum Pathol 35: 143-146, 2004.
Yaziji H, Goldstein LC, Barry TS, Werling R, Hwang H, Ellis GK, Gralow JR, Livingston RB, Gown AM. HER-2 testing in breast cancer using parallel tissue-based methods. JAMA 291: 1972-1977, 2004.
Werling RW, Hwang H, Yaziji H, Gown AM. Immunohistochemical distinction of invasive from noninvasive breast lesions: a comparative study of p63 versus calponin and smooth muscle myosin heavy chain. Am J Surg Pathol 27:82-90, 2003.
Werling RW, Yaziji H, Bacchi CE, Gown AM. CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: An immunohistochemical survey of 476 primary and metastatic carcinomas. Am J Surg Pathol 27:303-310, 2003.
Yaziji H, Gown AM. Immunohistochemical markers of melanocytic tumors. Int J Surg Pathol 11:11-15, 2003.
Beach R, Gown AM, De Peralta-Venturina MN, Folpe AL, Yaziji H, Salles PG, Grignon DJ, Fanger GR, Amin MB. P504S immunohistochemical detection in 405 prostatic specimens including 376 18-gauge needle biopsies. Am J Surg Pathol 26:1588-1596, 2002.
Gown AM. Genogenic immunohistochemistry: a new era in diagnostic immunohistochemistry. Current Diagnostic Pathology 8:193-200, 2002.
Yaziji H, Gown AM. Testing for HER2 in breast cancer: is fluorescence in situ hybridization superior in predicting outcome? Adv Anatom Pathol 9:338-344, 2002.
Yaziji H, Gown AM. Controversies and guidelines in tissue-based HER2 testing in breast cancer. MLO Med Lab Obs 34:12-16, 20-21, 2002.
Gown AM, Willingham MC. Improved detection of apoptotic cells in archival paraffin sections: immunohistochemistry using antibodies to cleaved caspase 3. J Histochem Cytochem 50:449-454, 2002.
Goldstein NS, Bassi D, Watts JC, Layfield L, Yaziji H, Gown AM. E-Cadherin reactivity of 95 noninvasive ductal and lobular lesions of the breast: implications for the interpretation of problematic lesions. Am J Clin Pathol 115:534-542, 2001.
Sneige N, Yaziji H, Mandavilli SR, Perez ER, Ordonex NG, Gown AM, Ayala A. Low-grade (fibromatosis-like) spindle cell carcinoma of the breast. Am J Surg Pathol 25:1009-1016, 2001.
Lehr HA, Jacobs TW, Yaziji H, Schnitt SJ, Gown AM. Quantitative evaluation of HER2 status in breast cancer by fluorescence in situ hybridization and by immunohistochemistry with image analysis. Am J Clin Pathol 115:814-822, 2001.
Agoff SN, Grieco VS, Garcia R, Gown AM. Immunohistochemical distinction of endometrial stromal sarcoma and cellular leiomyoma. Appl Immunohistochem Mol Morphol 9:164-169, 2001.
Stone CH, Lee MW, Amin MB, Yaziji H, Gown AM, Ro JY, Tetu B, Paraf F, Zarbo RJ. Renal angiomyolipoma. Arch Pathol Lab Med 125:751-758, 2001.
Goff BA, Paley PJ, Greer BE, Gown AM. Evaluation of chemoresistance markers in women with epithelial ovarian carcinoma. Gynecol Oncol 81:18-24, 2001.
Yaziji H, Gown AM. Immunohistochemical analysis of gynecologic tumors. Int J Gynecol Path 20:64-79, 2001.
Jacobs T.W., Gown A.M., Yaziji H., Barnes M.J., Schnitt S.J. HER2 protein expression in breast cancer evaluated by immunohistochemistry. A study of interlaboratory agreement. Am J Clin Pathol 113: 251-258, 2000.
Paley PJ, Goff BA, Gown AM, Greer BE, Sage EH. Alterations in SPARC and VEGF immunoreactivity in epithelial ovarian cancer. Gynecol Oncol 78:336-341, 2000.
Lehr HA, Folpe A, Yaziji H, Kommos F, Gown AM. Cytokeratin 8 immunostaining pattern and E-cadherin expression distinguishing lobular from ductal breast carcinoma. Am J Clin Pathol 114:190-196, 2000.
Yaziji H, Sneige N, Gown AM. Detection of stromal invasion in breast cancer: The myoepithelial markers. Adv Anatom Pathol 7:100-109, 2000.
Zarbo RJ, Prasad AR, Regezi JA, Gown AM, Savera AT. Salivary gland basal cell and canalicular adenomas: immunohistochemical demonstration of myoepithelial cell participation and morphogenetic considerations. Arch Pathol Lab Med 124:401-405, 2000.
Folpe A.L., Gown A.M., Lamps L.W., Garcia R., Dail D.H., Zarbo R.J., Schmidt R.A. Thyroid transcription factor-1: immunohistochemical evaluation in pulmonary neuroendocrine tumors. Mod Pathol 12: 5-8, 1999.
Jacobs T.W., Gown A.M., Yaziji H., Barnes M.J., Schnitt S.J. Comparison of fluorescence in situ hybridization and immunohistochemistry for the evaluation of HER2 in breast cancer. J Clin Oncol 17: 1974-1982. 1999.
Jacobs T.W., Gown A.M., Yaziji H., Barnes M.J., Schnitt S.J. Specificity of HercepTest™ in determining HER2 status of breast cancers using the United States Food and Drug Administration-approved scoring system. J Clin Oncol 17: 1983-1987, 1999.

History

Member for
3 years 14 weeks